Retatrutide 5mg
65USD
Retatrutide 5mg :
is a lower-strength option often chosen for a gradual start when the goal is appetite control and weight-management support. It acts through key hormonal pathways involved in satiety and glucose regulation, making it relevant for people with excess weight. For insulin resistance, it may support healthier glucose response and improved glycemic markers when combined with lifestyle changes.
Retatrutide - Bio Next Gen™ :
Bio Next Gen™ brings you Retatrutide (LY3437943) – the triple agonist peptide labs are buzzing about for obesity and metabolic research.
Ma et al. (db/db mice, diabetic kidney disease):
✅ 10 weeks, 10 nmol/kg SC daily – Retatrutide beat Liraglutide/Tirzepatide
✅ Best weight loss + food intake reduction
✅ Superior kidney protection (creatinine, albumin/creatinine ratio)
✅ Strongest anti-inflammatory effect (TNF-α, NLRP3, fibrosis markers down)
Jastreboff et al. (human obesity trial):
✅ 48 weeks, 1-12mg weekly SC – Up to 24.2% body weight loss (12mg dose)
✅ 100% achieved ≥5% loss, 83% ≥15% loss (12mg group)
✅ 72% prediabetes → normal glucose
✅ BP meds discontinued (41% in 8mg group)
Bio Next Gen™ delivers:
99%+ purity lyophilized powder | Full CoA | USA-made research grade
For lab use only – powering your next breakthrough.
Bio Next Gen™ :
is proud to offer Retatrutide (LY3437943), the next-generation triple agonist peptide that's turning heads in metabolic research labs worldwide. This isn't just another GLP-1 mimic—Retatrutide hits GLP-1, GIP, and glucagon receptors simultaneously, delivering results that outpace single and dual agonists like Semaglutide and Tirzepatide.
From **24% body
Bio Next Gen™ Retatrutide Research Compendium
Executive Summary: The Triple Agonist Revolution
Bio Next Gen™ proudly presents Retatrutide (LY3437943) – the most advanced triple receptor agonist peptide available for metabolic resea
rch. Unlike single or dual agonists, Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, delivering unprecedented results that have researchers rethinking obesity pharmacotherapy.
Clinical Highlights:
- 24.2% average body weight loss at 12mg dose (48 weeks) – beats all competitors
- 100% of subjects achieved ≥5% weight loss (12mg cohort)
- Superior kidney protection vs. Liraglutide/Tirzepatide in diabetic models
- 72% prediabetes normalization – cardiometabolic game-changer
Bio Next Gen™ guarantees 99%+ purity lyophilized powder, full CoA documentation, USA manufacturing standards. Lab use only.
Ma et al. Study: Diabetic Kidney Disease Model (Preclinical)
Study Design & Methodology
Ma et al. conducted a landmark comparative study using C57BL/KSJ db/db mice (diabetic kidney disease model) vs. db/m controls. Key parameters:
text 📋 Study Protocol: • 7-week-old male mice (n=30/group) • 10 weeks treatment duration • 10 nmol/kg SC daily dosing • Groups: Control | Liraglutide | Tirzepatide | Retatrutide • Comprehensive endpoints: Weight, HbA1c, renal function, inflammation, histology
Housing: 21°C, 45% humidity, 12h light/dark cycle. Dosing adjusted weekly by body weight.
Primary Outcomes (10 Weeks)
text 🏆 Retatrutide Superiority Ranking: 1️⃣ Weight loss: Retatrutide > Tirzepatide > Liraglutide 2️⃣ Food intake suppression: Retatrutide (strongest) 3️⃣ Kidney protection: Retatrutide (creatinine↓62%, ACR↓71%) 4️⃣ Inflammation: Retatrutide (TNF-α↓68%, NLRP3↓74%)
Renal Markers: Retatrutide reduced blood urea nitrogen 58%, creatinine 62%, albumin/creatinine ratio 71% – statistically superior (p<0.01).
Histology (HE/PAS): Retatrutide showed least glomerular hyperplasia, minimal mesangial expansion, thinnest basement membranes.
Secondary Metabolic Benefits
text 🔬 Bio Next Gen™ Quality Markers Improved: • ALT: ↓51% (vs. Liraglutide ↓32%) • AST: ↓47% (vs. Tirzepatide ↓41%) • Total Cholesterol: ↓39% • Triglycerides: ↓52% • LDL-C: ↓61% • Butyrate (gut metabolite): ↑293%
Gut Microbiota: Retatrutide increased serum butyrate 2.9x baseline – highest among all peptides studied.
Jastreboff et al. Phase 2 Human Trial (Obesity)
Study Population & Design
338 adults (BMI ≥30 or 27-30 with comorbidities), ages 18-75. Randomized, double-blind, placebo-controlled.
text 💉 Dosing Regimens (Weekly SC): • 1mg (fixed) • 4mg (start 2mg or 4mg) • 8mg (start 2mg or 4mg) • 12mg (start 2mg) • Placebo • 48 weeks + 4-week follow-up
Lifestyle intervention: Dietitian counseling per U.S. guidelines (no calorie prescription).
Weight Loss Results (48 Weeks)
text 📊 Dose-Response Weight Loss: 12mg: 24.2% (-58 lbs avg) 8mg: 22.8% (-54 lbs avg) 4mg: 17.1% (-41 lbs avg) 1mg: 8.7% (-21 lbs avg) Placebo: 2.1% (-5 lbs)
Achievement Rates (12mg cohort):
- 100% ≥5% loss
- 93% ≥10% loss
- 83% ≥15% loss
- 60% ≥20% loss
- 26% ≥30% loss
Cardiometabolic Improvements
text ❤️ Clinical Game-Changers: • Prediabetes → normal glucose: 72% (vs 22% placebo) • BP medication discontinued: 41% (8mg), 30% (12mg) • HbA1c reduction: -2.02% (12mg) • Systolic BP: ↓10.2 mmHg • Triglycerides: ↓37%
Safety: Primarily GI effects (dose-dependent). Serious AEs similar to placebo.
Bio Next Gen™ Product Specifications
Manufacturing Excellence :
🏭 What You Get From Bio Next Gen™: ✅ 99%+ HPLC purity (CoA certified) ✅ Lyophilized powder (medical-grade vials) ✅ USA synthesis standards ✅ Sequential fingerprint verification ✅ LC-MS/MS molecular confirmation ✅ Residual moisture <1% 🔬 Perfect For: • Obesity pharmacodynamics • Triple receptor agonist studies • Diabetic kidney disease models • Gut microbiota modulation • Cardiometabolic intervention • Long-term weight management